Identification of amino acids in highly pathogenic avian influenza H5N1 virus hemagglutinin that determine avian influenza species specificity
Identifieur interne : 002275 ( Main/Exploration ); précédent : 002274; suivant : 002276Identification of amino acids in highly pathogenic avian influenza H5N1 virus hemagglutinin that determine avian influenza species specificity
Auteurs : Zheng Li [République populaire de Chine] ; Zhonghua Liu [République populaire de Chine] ; Chi Ma [République populaire de Chine] ; Linqi Zhang [République populaire de Chine] ; Yuelong Su [République populaire de Chine] ; George F. Gao [République populaire de Chine] ; Zi Li [République populaire de Chine] ; Lianxian Cui [République populaire de Chine] ; Wei He [République populaire de Chine]Source :
- Archives of Virology [ 0304-8608 ] ; 2011-10-01.
Abstract
Abstract: To test the role of neutralizing antibodies (nAbs) and receptor adaptation in interspecies transmission of influenza virus, two H5N1 strains, isolated from human and avian hosts, with four amino acid differences in hemagglutinin (HA) and seven HA mutations were studied. We found that a mutation at amino acid position 90 in the H5N1 HA, outside the receptor-binding domain (RBD), could simultaneously induce changes in the RBD conformation to escape from nAb binding and alter the receptor preference through long-range regulation. This mutation was deemed a “key event” for interspecies transmission. It is likely a result of positive selection caused by antibodies, allowing the original invasion by new species-specific variants. A mutation at amino acid position 160 in the RBD only induced a change in receptor preference. This mutation was deemed a “maintaining adaptation”, which ensured that influenza virus variants would be able to infect new organisms of a different species successfully. The mutation is the result of adaptation caused by the receptor. Our results suggest that continuing occurrence of these two types of mutations made the variants persist in the new host species.
Url:
DOI: 10.1007/s00705-011-1056-2
Affiliations:
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We found that a mutation at amino acid position 90 in the H5N1 HA, outside the receptor-binding domain (RBD), could simultaneously induce changes in the RBD conformation to escape from nAb binding and alter the receptor preference through long-range regulation. This mutation was deemed a “key event” for interspecies transmission. It is likely a result of positive selection caused by antibodies, allowing the original invasion by new species-specific variants. A mutation at amino acid position 160 in the RBD only induced a change in receptor preference. This mutation was deemed a “maintaining adaptation”, which ensured that influenza virus variants would be able to infect new organisms of a different species successfully. The mutation is the result of adaptation caused by the receptor. Our results suggest that continuing occurrence of these two types of mutations made the variants persist in the new host species.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name></noRegion><name sortKey="Cui, Lianxian" sort="Cui, Lianxian" uniqKey="Cui L" first="Lianxian" last="Cui">Lianxian Cui</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name><name sortKey="Li, Zi" sort="Li, Zi" uniqKey="Li Z" first="Zi" last="Li">Zi Li</name><name sortKey="Liu, Zhonghua" sort="Liu, Zhonghua" uniqKey="Liu Z" first="Zhonghua" last="Liu">Zhonghua Liu</name><name sortKey="Ma, Chi" sort="Ma, Chi" uniqKey="Ma C" first="Chi" last="Ma">Chi Ma</name><name sortKey="Su, Yuelong" sort="Su, Yuelong" uniqKey="Su Y" first="Yuelong" last="Su">Yuelong Su</name><name sortKey="Zhang, Linqi" sort="Zhang, Linqi" uniqKey="Zhang L" first="Linqi" last="Zhang">Linqi Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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